Beyond The Sunset: A Pathway-Driven Vision For Personalized Cancer Care And Recovery

Foreword vi
Preface xvii

Mini Bio Lesson –A Quick Guide to Learn About Words Related to Cancer Biology 1

Chapter 1 Defining Cancer - A Disease Beyond Therapy
Historical Perspective of Cancer 20
Current Understanding of Cancer as a Systemic Disease 22
The Limitations of Traditional Cancer Therapies 25

Chapter 2 Four Major Characteristics of Cancer
Invasiveness 32
Metastasis 35
Heterogeneity 38
Resistance 41

Chapter 3 The Nucleolus – The Hidden Origin of Cancer
Overview of the Nucleolus in Cellular Biology 46
Nucleolar Dysfunction and Stress in Tumor Evolution 50
NPM1/B23 – A Key Player in Cancer Development 53
Why Nucleolar Balance Matters – A Prelude to NPM1’s Wider Impact 55

Chapter 4 NPM1 and Gene Co-expression Networks in Cancer
NPM1 as a Molecular Hub in Cancer Signaling 58
Gene Co-Expression Analysis in Cancer Progression 60
Identifying Potential Therapeutic Targets Through NPM1 Networks 63

Chapter 5 The QGCT® Model – A New Perspective on Cancer
Introduction to the QGCT® Model 66
Key Components and Pathways in QGCT® 68
Predicting Pathway Dysregulation Ranking for Individual Patients 71

Chapter 6 The Seven Key Pathway Classes – Shaping Cancer Phenotypes
Inflammation and Cytokine Response 74
Cellular Stress and Oxygen Response 76
Cellular Growth, Proliferation, and Survival 78
Angiogenesis and Tissue Remodeling 80
Metabolism and Lipid Signaling 82
Protein Homeostasis 84
Stemness, Differentiation, and Development 86

Chapter 7 Pathway-Based Supplements –A New Era in Supportive Therapy
Rationale Behind Developing A Pathway-Based Supplement 90
Comparison with Existing Cancer Supplements 92
Key Pathway-Targeted Ingredients and Their Mechanisms of Action 94
A Systems-Based Vision for Multi-Compound Integration 104

Chapter 8 Clinical Insights from QGCT® –Bridging Analysis and Possibility
Mapping Therapeutic Possibilities in Complex Cases 110
Informing Future Support Strategies Through Pathway Profiling 112
Long-Term Benefits of Targeting Cancer Pathways 115
Future Perspectives on Personalized Cancer Care 117

References 121
Tributes 133

BENJAMIN YAT-MING YUNG
Professor Benjamin Yat-Ming Yung is a distinguished scientist and educator, trained at world-renowned institutions, including Stanford University. His decades of research on the nucleolar protein NPM1/B23 have now culminated in the world's first pathway network model for cancer drug resistance and recurrence, unlocking new possibilities in precision oncology and offering hope to millions worldwide. This book distills his revolutionary insights, blending cutting-edge science with a transformative, personalized approach to cancer care.

From historical foundations to contemporary innovations, from data interpretation to clinical application－this book charts a visionary path toward a future in which cancer therapy is not only more effective, personalized, but also more compassionate.
Professor Kwong-Kwok Wong, the MD Anderson Cancer Center

A testament to how an unwavering pursuit of scientific ideals, grounded in conviction and passion, can lead to transformative breakthroughs in medicine.
Yu-Sun Chang, Ph.D., Professor, Chang Gung University

This book represents the culmination of decades of thoughtful research and genuine care for cancer patients. It offers hope grounded in rigorous science—exactly what our field and our patients need.
Jason Lih, Ph.D., Vice President of R&D, Apeximmune Therapeutics