Beyond The Sunset: A Pathway-Driven Vision For Personalized Cancer Care And Recovery | 誠品線上

日落之那邊: 通路導向的癌症精準治療與康復新思維

內容簡介

內容簡介 Unlock Pathway Codes, Reshape Cancer FightProfessor BENJAMIN YAT-MING YUNG, former Professor in the Department of Pharmacology at Chang Gung University College of Medicine, draws on forty years of accumulated research on NPM1 B23 to present the world's first network model of cancer drug resistance and recurrence pathways.This book breaks free from traditional therapy frameworks, delving into the four major characteristics of cancer to reveal the core pathogenesis of nucleolar imbalance and analyze the regulatory mechanisms of seven key pathway categories. The breakthrough QGCT® deconstructs personalized dysregulated pathways for patients, while providing pathway-based supplement applications and clinical solutions.More than just a popular science introduction to cancer knowledge, it offers patients new directions in precision treatment and provides scientific prevention strategies for health-conscious individuals. By integrating cutting-edge science with personalized care, it transforms the arduous journey of fighting cancer into a clear, navigable path to recovery.

各界推薦

各界推薦 From historical foundations to contemporary innovations, from data interpretation to clinical application－this book charts a visionary path toward a future in which cancer therapy is not only more effective, personalized, but also more compassionate.Professor Kwong-Kwok Wong, the MD Anderson Cancer CenterA testament to how an unwavering pursuit of scientific ideals, grounded in conviction and passion, can lead to transformative breakthroughs in medicine.Yu-Sun Chang, Ph.D., Professor, Chang Gung UniversityThis book represents the culmination of decades of thoughtful research and genuine care for cancer patients. It offers hope grounded in rigorous science—exactly what our field and our patients need.Jason Lih, Ph.D., Vice President of R&D, Apeximmune Therapeutics

作者介紹

作者介紹 BENJAMIN YAT-MING YUNGProfessor Benjamin Yat-Ming Yung is a distinguished scientist and educator, trained at world-renowned institutions, including Stanford University. His decades of research on the nucleolar protein NPM1 B23 have now culminated in the world's first pathway network model for cancer drug resistance and recurrence, unlocking new possibilities in precision oncology and offering hope to millions worldwide. This book distills his revolutionary insights, blending cutting-edge science with a transformative, personalized approach to cancer care.

產品目錄

產品目錄 Foreword viPreface xviiMini Bio Lesson –A Quick Guide to Learn About Words Related to Cancer Biology 1Chapter 1 Defining Cancer - A Disease Beyond TherapyHistorical Perspective of Cancer 20Current Understanding of Cancer as a Systemic Disease 22The Limitations of Traditional Cancer Therapies 25Chapter 2 Four Major Characteristics of CancerInvasiveness 32Metastasis 35Heterogeneity 38Resistance 41Chapter 3 The Nucleolus – The Hidden Origin of CancerOverview of the Nucleolus in Cellular Biology 46Nucleolar Dysfunction and Stress in Tumor Evolution 50NPM1 B23 – A Key Player in Cancer Development 53Why Nucleolar Balance Matters – A Prelude to NPM1’s Wider Impact 55Chapter 4 NPM1 and Gene Co-expression Networks in CancerNPM1 as a Molecular Hub in Cancer Signaling 58Gene Co-Expression Analysis in Cancer Progression 60Identifying Potential Therapeutic Targets Through NPM1 Networks 63Chapter 5 The QGCT® Model – A New Perspective on CancerIntroduction to the QGCT® Model 66Key Components and Pathways in QGCT® 68Predicting Pathway Dysregulation Ranking for Individual Patients 71Chapter 6 The Seven Key Pathway Classes – Shaping Cancer PhenotypesInflammation and Cytokine Response 74Cellular Stress and Oxygen Response 76Cellular Growth, Proliferation, and Survival 78Angiogenesis and Tissue Remodeling 80Metabolism and Lipid Signaling 82Protein Homeostasis 84Stemness, Differentiation, and Development 86Chapter 7 Pathway-Based Supplements –A New Era in Supportive TherapyRationale Behind Developing A Pathway-Based Supplement 90Comparison with Existing Cancer Supplements 92Key Pathway-Targeted Ingredients and Their Mechanisms of Action 94A Systems-Based Vision for Multi-Compound Integration 104Chapter 8 Clinical Insights from QGCT® –Bridging Analysis and PossibilityMapping Therapeutic Possibilities in Complex Cases 110Informing Future Support Strategies Through Pathway Profiling 112Long-Term Benefits of Targeting Cancer Pathways 115Future Perspectives on Personalized Cancer Care 117References 121Tributes 133

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推薦序 : In 2014, during a visit to Hong Kong, I had the distinct honor of being introduced to Professor Yung through a mutual colleague. Later that year, he and his research team visited Houston, where I had the privilege of hosting them and arranging a tour of the MD Anderson Cancer Center. During this visit, Professor Yung delivered a compelling seminar titled “A Multidisciplinary Research on Cancer and Its Metabolic Risk Factor: From Computational Characterization, Functional Discovery to Clinical Diagnostics Development.” His presentation was both intellectually rigorous and clinically insightful—an exemplary fusion of biochemical depth, computational sophistication, and translational relevance.

Now, more than a decade later, I am filled with admiration as I witness the culmination of Professor Yung’s enduring commitment to cancer research in this seminal volume. This publication transcends conventional scientific discourse. It stands as a testament to the transformative power of integrative research—serving as a beacon of hope for patients, a strategic guide for clinicians, and a source of inspiration for investigators navigating the complexities of cancer biology.

Professor Yung’s scholarly journey spans over four decades, beginning with foundational biochemical and genetic investigations into NPM1/B23—a multifunctional protein central to both physiological regulation and oncogenic processes. His research evolved to encompass computational analyses of NPM1/ B23 co-expressed genes, illuminating regulatory aberrations and delineating gene co-expression networks. This progression—from molecular characterization to computational modeling—has yielded a novel framework for understanding and addressing cancer pathogenesis.

His dedication to the study of NPM1/B23 culminated in the development of QGCT®, a proprietary computational architecture designed to extract clinically actionable insights from transcriptomic data. QGCT® represents a significant advancement in precision oncology, empowering clinicians to identify and prioritize functionally critical pathways that may underlie therapeutic resistance, disease recurrence, or treatment failure. QGCT® also introduces a paradigm shift: conceptualizing cancer as a network-based disease amenable to intervention through targeted disruption of its critical systems. This innovative perspective on supportive oncology care marks a promising evolution in the pursuit of holistic, patient-centered treatment strategies.

From historical foundations to contemporary innovations, from data interpretation to clinical application—this book charts a visionary path toward a future in which cancer therapy is not only more effective, personalized, but also more compassionate. It is with the utmost respect and enthusiasm that I commend this important work to the scientific and medical communities.

Kwong-Kwok Wong, Ph.D.
Professor
The University of Texas MD Anderson Cancer Center

最佳賣點

最佳賣點 : Unlock Pathway Codes, Reshape Cancer Fight

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